Perfenazin hemmer omdannelsen fra kodein til den aktive metabolitten morfin via CYP2D6 og vil dermed kunne gi nedsatt analgetisk effekt av kodein.Loss of life as well as the need of the liver transplant may additionally arise. Metabolism by the CYP2E1 pathway releases a toxic acetaminophen metabolite often known as N-acetyl-p-benzoquinoneiminePga.

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